Ayurveda-2

It is rightly said that Ayurvedic treatments even cure Karmic diseases. When a traditional Ayurvedic treatment is given as explained here the individual changes his thought processes. When the thought processes are changed actions are changed. Change in actions changes Karma of the individual. Such is the simple understanding of this great Health science. Disease according to Ayurveda is an expression of one's karma to be corrected. Physical disease warrants the attention that the Individual needs to his Awareness to the next higher level. It is the stepping stone to the next level of Evolution.

    Modern scientific research gives the very logical understanding that the diseases are caused through defective expression of the genes, which in turn is influenced by life style of the individual which includes the food eating habits. Unfortunately  Modern science focused only on the body and so have left it unaware of the deeper implications of the Mind that Ayurveda explains. We will now go to the details of the Mind and the Cosmic laws operating at the Universe level and the Individual level.

   The five Pancha Bhoota principles of Expansion, localization, Interaction, transformation and combinations at the Cosmic level also operate  as the five senses in the body. This is how the individual body is connected to the Cosmic level. Our sense organs are not mere organs of the body, but the very tools to experience the Cosmic phenomenon.  The Indriyas (Senses) act as a bridge between the mind and the physical world outside. Primary cause of disease is the improper use of the senses, Insufficient sensory inputs and the emotional imbalance it causes.

    Ayurveda understands that it is the nature of the mind that is the root cause of sufferings and diseases. Hence to settle the mind, it also employs the use of Yoga and Meditation. Like other Vedic disciplines it also incorporates spiritual aspect in the individual. A very traditional Ayurvedic Vaidya (doctor) uses pulse diagnosis through which he or she understands the functioning of the body.

  Reflects Tridhoshas Senses perception Organ Action
Aakash-Ether Expansion Vaata Hearing Ear Hearing
Vayu-Air localization Vaata Touch Skin Holding
Agni-Fire Interactions Pitta Vision Eye Walking
Jala-Water Transformations Kapha Taste Tongue Procreation
Prithvi-Earth Combinations Kapha Smell Nose Excretion

Other interpretations

Insights from Ayurveda for translational stem cell research

Kalpana S. Joshi and Ramesh Bhonde

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012361/?report=reader

Ayurveda physiology explains a dynamic exchange between in terms of continuous regeneration of tissues. The tissues undergo continuous process of destruction and regeneration. The homeostasis is maintained by Doshas, those regulate all the metabolic processes. Vata regulates the catabolic activity (tissue wear and tear), Kapha stimulates synthesis of newer tissues, and Pitta governs the process of nutrients assimilation into tissues. Dosha act through body tissue, Ayurveda terms those as Dhatus (Sanskrit meaning to hold or withstand). Ayurveda recommends several dietary, lifestyle, and herbomineral interventions for Dosha balance and Dhatu nourishment resulting in healthy long life. Traditionally therapies such as Panchakarma and Rasayana are used in Ayurveda for rejuvenation. Current knowledge on adult and embryonic stem cells if used along with concepts of regeneration in Ayurveda can contribute to the development of regenerative medicine with integrative approach

 STEM CELL BIOLOGY

Stem cell research is being pursued in the hope of achieving major medical breakthroughs in treatment of diseases. Stem cells are self-renewing, unspecialized cells that can give rise to multiple cell types of all tissues of the body. Somatic or adult stem cells typically generate the cell types of the tissue in which they reside. For example, a blood-forming adult stem cell in the bone marrow normally gives rise to the many types of blood cells. It is generally accepted that a blood-forming cell in the bone marrow—which is called a hematopoietic stem cell—cannot give rise to the cells of a very different tissue, such as nerve cells in the brain. Experiments over the last several years have purported to show that stem cells from one tissue may give rise to cell types of a completely different tissue, a phenomenon known as plasticity. Examples of such plasticity include blood cells becoming neurons, liver cells that can be made to produce insulin, and hematopoietic stem cells that can develop into heart muscle. Therefore, exploring the possibility of using adult stem cells for cell-based therapies has become a very active research area.[20]

In recent years, several lines of evidence have suggested that adult stem cells are multipotent and can differentiate into different cell lineages. Adult bone marrow, brain, skeletal muscle, liver, pancreas, fat, skin, and skeletal muscle, have all been shown to possess stem or progenitor cells with the capacity to differentiate into cell types other than their tissue of origin.

Studies with bone marrow stromal or MSCs, a subset of cells that can be separated by plastic adherence, have shown differentiation into various cell types, including bone,[21,22] tendon, cartilage, and fat.[23] Stem cells, directed to differentiate into specific cell types, offer the possibility of a renewable source of replacement cells and tissues to treat diseases including Parkinson's and Alzheimer's diseases, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis.[24]

BIOMEDICAL INTERPRETATION OFDHATU

Ayurveda mentions about emergence of various Dhatus in a sequence such as “Rasa, Rakta-Mamsa, Meda, Asthi, Majja, and Shukra”.[29] These Dhatus develop sequentially and nourish further Dhatus. For example, Rakta Dhatus plays important role in formation of Mamsa, which further nourishes Meda. The concept of Dhatus from Ayurveda and that of 

modern biology are different, but can be interpreted according their descriptions and functions. These Dhatus cannot be directly equated to various tissues; however, each tissue is formed by composition of many Dhatus. Respective Dhatus are dominant in specific tissues. There is a possibility that there is presence of stem cells in a particular tissue (Dhatu) giving rise to the next Dhatus in sequence.

Adult bone marrow stromal cells are shown to differentiate into neural cells in vitro by treating them in presence of epidermal growth factor (EGF) or brain-derived neurotrophic factor (BDNF), expressed the protein and mRNA for nestin, a marker of neural precursors.[20] Human adipose tissue obtained from liposuction procedures has also been used to isolate a fibroblast-like cell population, called processed lipoaspirate (LPA) cells. In vitro studies with LPA cells demonstrated differentiation into adipogenic, chrondogenic, myogenic, and osteogenic cells.[30] Ayurvedic concept of Dhatu needs to be explored on this background. The focus of Ayurveda intervention is to protect and nourish Dhatus to form healthy body is similar that of modern medicine. Unlike Prakriti, which is permanent composition of Doshas, Dhatu concept is dynamic and changes according to diet and drugs. The quality and quantity of Dhatus can change with Rasayana and the depleted Dhatus could be nourished. Thus, the Dhatu concept is the foundation of Rasayana therapy and regeneration of tissues. It is interesting to note that the description of Dhatus fromRasa to Shukra require different dosage forms ranging from aqueous to medicated oils or ghee.

We propose specific Rasayana with appropriate extract and formulation for its effects on stem cells. The experiment can also consider the variations of extracts according to the nature of Dhatus (cell type)