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Why Protect Heritage?

Our mission is to protect culture by preserving ancient cultural heritage. Why do we need culture?. Culture preserves the most valubale aspect of human, the mind. We document many ancient methods in health science, education, etc in this site. Why do we need old when we are evolving to modern ways?  What will happen if we dont preserve culture?

Here is a simple story to illustrate the point.

Once there was a prince who immediately after the throning ceremony ordered to kill all old people above because they are not good looking and cannot work energetically and a waste to feed them at home.  Everybody thought it made sense and killed their parents, except one young man in the village. He hid his parents in an attic. In spring when the people wanted to do farming, they did not know how to get the rice seeds because they have used up all of them in the winter. They felt bad that they had killed that information by killing all the old people who had that knowledge. Now they really repented for it but nobody had a solution.

The youngman told about his old parents in the attitic. The majestic king went in person to meet the old guys in attitic because they now suddently became so valuable. The old parents asked the king to look for the sporuting rice plants from the seeds that accidently fell down when they carried from farmland to market. He carefully replanted the rice plants in farmland. From then on started the practice of transplanting rice spalings from one field to another.

The king was overjoyed and congradulated the youngman for reviving farming and saving everyone from famine, by preserving his old parents. The king understood his mistake and ordered that everybody should take care of their old parents for their guiding wisdom.

This story is a symbolic of the work Uni5 Sakthi Foundation does by documenting all the ancient methods. One day when we dont understand the importance of wisdom, we will have this site to refer and revive humanity.We have five levels of information ...on health, relationships, education, selftual Awareness for being happy and Consciousness for eternity. Any time we want to most valuable information/knolwedge, this site will have it.

Please donate to the help these projects for everybody's future.

 We are planning to support Heritage in several countures.

1. Aranmula Heritage Project

2. Angor Vat heritage Project

My grandma super too

Other folk-lore tales.

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https://www.sciencedaily.com/releases/2006/09/060919102046.htm

https://www.rit.edu/news/umag/spring2007/08_features_Leaves_of_gold.html

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Resume

Dr. MADESWARAN   MOHAN, M.A., Ph.D

Chennai, Coimbatore, India

 Director, Sakthi Foundation Uni5 Schools (Since 2007)

Teaching:

Over 17 years’ experience in teaching middle level and senior level school

Conducting Montessori – Uni5 teacher training course to suburban women in Tamil language for 1 – 6 years.

2012 January – since – Montessori language consultant in Redwoods Montessori school - Chennai

2011 – since – part time language consultant in Vruksha Monteessori school - Chennai

2007 – since director of Sakthi Montessori – Uni5 centers [Sendurai, Poraiyar and Coimbatore]

Elementary Montessori language Director,   Abacus Montessori Icse School, Chennai ,[2001-2010 ]

Biology teacher and Tamil Assistant...Jaycees Matriculation Higher Secondary School,Erode....[2000...June To December]

Biology teacher and Tamil Language Assistant...Barathy Vidya Bhavan Matriculation Higher Secondary School, Erode..[1996...1999]

Publications:

Co-Authored the Book “Diet and Cancer” Maruthi Publishers, 1997.

Writes articles on culture, tradition, child education, Montessori education, epics and mythologies [Uni5 periyapuranam, uni5 Thiruvilayadal puranam and uni5 mahabaktha vijayam].

Translates Montessori articles in Tamil.

Educational:

• Ph.D (Doctorate in Philosophy): Literary Criticism On Tamil Language Of 14 A.D. Bharathidasan .University , 2002.
• Diploma In Montessori  Training For primary and elementary Level.
• Bachelor degree in Bio-chemistry: Bharathiyar University-1994: Anatomy & physiology, Chemistry, Bio-physics and Bio-chemistry.
• Masters in   Tamilology: M.K.University. 1996

Primary, Middle & High School: Bharathy vidya bavan matriculation school (4000 students) and left as the best outgoing student of the year (1991).

             English, Science, Math, Social Science.

Teaching Experience: 1996 – Present:

Other Artistic talents.

• Best Out Going Student Of My School In 1991.
• Know South Indian Music,
• Effective in delivering public talks on general topics
• Did research and collected information on Ancient architecture and history for a Tourism developing company in Madurai, India.
• Painting - Created New Pattern Of Line Drawing On Old Legends. Published in many magazines for their uniqueness
• Conducting Uni5 personality sessions for corporates, students, teachers and parents.
• Conducts workshop for parenting and child development
• Conducts CAC sessions to promote uni5 concept in Coimbatore and Chennai.

click below the youtube video

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Pradheep Chhalliyil

About:

Dr. Pradheep Chhalliyil is a multifaceted individual, serving as a Scientist, Entrepreneur, Author, and Educationalist. With numerous patents, scientific papers, and books to his name, his expertise spans various domains. Notably, his groundbreaking research led to the discovery of a plant-based anticancer compound, earning him a PhD in Cancer Biology. This discovery is currently undergoing clinical trials, promising hope for cancer treatment.

Having worked as a postdoctoral fellow at the prestigious Roswell Park Cancer Institute in New York, Dr. Chhalliyil's contributions to the field of Food Biotechnology in the USA for over two decades have been significant. He has notably advanced DNA extraction techniques and tackled the issue of food adulteration.

As the founder of UNI5 Sakthi Foundation Schools, Dr. Chhalliyil has revolutionized education by introducing an energy-pattern based learning system, fostering efficient learning alongside holistic personal development. Applying similar pattern-based approaches to health, he has provided complimentary treatments to thousands, addressing various diseases effectively.

Furthermore, Dr. Chhalliyil has pioneered Microbiome testing, utilizing advanced methodologies to identify the root causes of diseases, thereby enabling more precise and targeted treatment strategies. This innovative approach goes beyond conventional lab tests, linking clinical manifestations to food quality testing.

His latest book delves into profound mysteries, exploring topics such as Consciousness, the creation of the Universe, energy vibrations, and the mathematical intricacies of life and death. It serves as a comprehensive guide to understanding "Everything," offering insights into the fundamental questions of humanity.

More

 He is the  cofounder or AMMAGENOMICS, OORJV and MA Omics which gives extensive testing in diagnostics, food, supplements and certification. 

His team offers comprehensive diagnostic testing and  treatment plan for all diseases including cancer, diabetes, infertility, kidney, cardiac and liver disorders and also for pyshlogical problems and challenges of autism, ADDH etc.  He is a part of a medical team overseeing care, specifically focusing on diet, probiotics, and nutritional supplements as complementary treatments. In addition to conventional medical interventions, he utilizes microbial 16s sequencing, genetic testing, RT-PCR-based inflammation markers, and cancer markers diagnosis to enhance the accuracy of treatment prognosis. These tests play a crucial role in helping the patient manage the limitations of other treatments and side effects and facilitate a healthier life. 

His team has expertise to solve challenges in the application of RNA, DNA for molecular biology applications like qPCR, Digital PCR, DNA sequencing etc. 

Dr. Chhalliyill has 30 plus years of professional scientific experience. In 1997, Dr. Challiyil co-founded a 503(c) tax-exempt non-profit organization called Sakthi Foundation. He also started a Sakthi Schools, a subsidiary of Sakthi Foundation. Today, there are several Sakthi Schools operation in Southern India. In addition, he developed a new effective, integrated and holistic education system known as the Uni5 system of education. In fact, all the Sakthi Schools, as well as few other schools in India, are adopting this Uni5 system of education.

Sakthi Foundation website will provide an immense amount of information ranging from health, happiness, relationship, pattern-based education, parenting, energy, and spirituality. He has delivered numerous lectures all around the globe. He also provides advice through zoom, whatsapp & telegram groups on the above topics.

https://www.linkedin.com/in/pradheep-chhalliyil-1096b93/

Resume

PROFESSIONAL EXPERIENCE

Co-Founder & Chief Scientific Officer                                                                                       March 2021-Present
Accurate Molecular Mutation Analytical Genomics (AMMAGENOMICS), Chennai, India  
Developing Technologies (Patent Pending) for Biotechnology, Medical, Pharmaceutical and Food Industry

CSO & Founder                                                                                                                  November 2021-Present

Oorjv Certification of Food and Herbal Medicines for quality and verification

Chief Scientific Officer                                                                                                           November 2021 -Present

YSA Labs, Tempe, Arizona, USA

Developed Technology and Patent Pending RNA Extraction Free Technology

Biotechnology Consultant                                                                                             August 2019-2020 (1 year)

SomaGenics, Inc. CA, USA                                                                                                                                                                                                        

Developed SNP assay

Molecular Diagnosis Director                                                                                          July 2020-January 2021

Diagnostic Lab Chennai, T.Nadu, India                                                                                      

Evaluated and implemented new technologies and laboratory techniques to facilitate high-throughput data acquisition.

Senior Scientist                                                                                                             April 2000- Jan 2019

Foodchain ID NA INC                                                                                                                                                                                                                    

19 years of experience as a Lead player in R&D, developing technologies for detecting GMO (Genetically modified organisms) allergens and monitoring food adulteration using qPCR and Digital PCR and sequencing methods, which were used by the company’s all branches and franchising units all over the globe.

Postdoctoral Fellow                                                                                                                                   1997-2000

Roswell Park Cancer Center                                      

Researched the cause of recurrence of cancer in patients who received chemotherapy for Leukemia.

Lecturer                                                                                                                                               1990-1992

PSGCAS, Coimbatore, India                                                                                                                              

Took the initiative in creating the course syllabus and establishing the curriculum for graduate and undergraduate students studying biochemistry and biotechnology.

PATENTS

• RNA and DNA High-Quality Extraction India, USA 2022-Patent Pending
• RNA single tube Extraction free Method USA 2021-Patent Pending
• A process for the isolation of the anticancer principle from medicinal plants (Cleistanthin) - India - 1539/MAS/95.
• An electrochemical process for water sterilization by singlet Oxygen production - 1622/MAS/95.

Inspiration to other organizations

1. Sakthi Foundation Non Profit Organization India - Sep 28th 1998 www.sakthifoundation.org 

2. Sakthi Foundation Non Profit Organization USA - Sep 28th 2000  www.rightawareness.com 

3. Uni5 Schools www.uni5schools.com 

4   https://www.sathgentherapeutics.com/company-history/#

EDUCATION & Certificates

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Madurai Kamaraj University, India

Ph.D., Effects of Cleistanthins on the Proliferation of Normal and Tumor Cells                                                           1998

Doctorate in Biochemistry & Cancer Biology                                                                                                        1992-1997

PSGCAS is affiliated with Bharathiyar University, Coimbatore, India

Masters in Biochemistry (Project- Cancer Serum levels of Acetyl Cholinesterase) 1990

Bachelors in Biochemistry                                                                                1988

Higher Secondary-Sri Baldevdas Kikani Vidyamandir High School -Coimbatore    1982-1985

High School-C.M.S. Vidya Mandir School, Ganapathy,Coimbatore (Old CBSE)     1977-1982

Elementary-Seventh Day Adventist School< kattoor, Coimbatore                         1971-1977

SKILLS AND ABILITIES

• Skilled in Primer Probe design to detect even single base pair change (point mutations) that helps in the detection of specific gene targets with high specificity and sensitivity.
• Skilled in developing Nucleic acid (RNA & DNA) extraction using Magnetic beads, spin columns, and direct PCR from all human samples, crops, plants, animals, insects, microbes, and soil.
• Skilled in developing diagnostic methods for clinical, research, environmental, and other applications.  
• Skilled in developing methods for Next-Gen Sequencing, metagenomics, and chromosome walking for flanking regions from all biological samples.
• Skilled in developing inhibition-free Master-mix, Digital PCR, Multiplex PCR, LAMP, and Chip-based technologies.
• Developed technologies to detect food adulteration, safety, assay for antioxidants, polyphenols, food components.
• Analytical and problem-solving skills.
• Multitasking abilities. 

LEADERSHIP

Co-Founder / Leaders (AMMAGENOMICS) Accurate Molecular Mutation                    11 November 2020-Present

Analytical Genomics                            

• Developing AMMAGENOMICS, a startup, to become one of Chennai's top 10 COVID testing labs in six months with a successful turnover that employs more than 50+ employers.
• Being a leader in the development of biotechnology products and services for a variety of industries, including the industrial, diagnostic, and testing sectors.
• Directing effective technical training for lab and professional training courses, internships, and externships.
• Using creative pattern-based teaching to lead the Uni5 School's curriculum development.
• Gave health tips for various diseases to thousands of people all over the globe using emails, web sites, social media, health awareness campaigns, talks etc.
• Amassing more than 24 million hits on the rightawarness.com website in 10 years.
• Using public speeches and literature to guide kids and adults through the Selftual (life purpose) questions.
• Directing the development of several food products that are marketed on kapilanalam.com and are both nutritional and therapeutic.
• Technologies were created and put into use by sales and management teams to provide quick turnaround of samples for business development.

PUBLICATIONS

In Press 

• Pradheep Chhalliyil   et al Adulteration in Milk and diary products in the Market
• Pradheep Chhalliyil  et al High Quality Microbiota Profile in Stool Samples using AMMAGENOMICS Microbial DNA Kit
• Pradheep Chhalliyil  et al Polyphenol Free DNA and RNA from plant samples using AMMAGENOMICS Plant DNA Kit
• Pradheep Chhalliyil  et al Quick Saliva DNA analysis using AMMAGENOMICS Saliva DNA Kit
• Pradheep Chhalliyil  et al  High sensitive Viral DNA and RNA detection in Blood Plasma samples using AMMAGENOMICS Blood DNA RNA Kit
• Pradheep Chhalliyil  et al  Metagneomics Profile of Soil Microbiota using AMMAGENOMICS Soil DNA Kit
• Pradheep Chhalliyil  et al  Enhanced Gram positive Bacteria Profiling using AMMAGENOMICS Microbial DNA Kit
• Pradheep Chhalliyil  et al Blood Fungal and Yeast detection made easy and efficient using AMMAGENOMICS Fungal DNA Kit
•  

https://orcid.org/0000-0001-9167-0621

• Chhaliyil Pranav, Schoel B, Chhalliyil Pradheep. Evaluation of Different Mulching Methods and Its Impact on Soil Microbiota. J Pure Appl Microbiol. Published online 09 October 2025. doi: 10.22207/JPAM.19.4.08  

  https://doi.org/10.22207/JPAM.19.4.08

• Pradheep Chhalliyil, Usha Nandini,  Uni5 Approach for Treating Inflammatory Disease: Case Reports on Atopic Eczema  International Journal of Sport, Exercise and Health Research 2024; 8(1): 22-25

• Pradheep Chhalliyil, Praveen Mayakrishnan, Silambarasan Kanesan, Usha Nandini. Uni5 Approach to Treat Psoriasis: A Case Report.  Journal of Ayurvedic and Herbal Medicine 2023; 9(4): 155-159

• Pranav Chhaliyil, Kael F Fischer, Bernd Schoel, Pradheep Chhalliyil. Impact of refined and unrefined sugar and starch on the microbiota in dental biofilmand starch on the microbiota in dental biofilm 2022:12:Issue:5:554-563

• Pradheep Chhalliyil, Usha Nandini, Neelima Thota. Successful pregnancy in a patient via holistic approach of uni5 based treatment with recurrent implantation failure: A case report of unexplained infertility. Panacea Journal of Medical Sciences 2022;12(3):708-713

• Pradheep Chhalliyil, Usha Nandini, Neelima Thota. UNI5 APPROACH TO TREAT VARICOSE ULCER: A CASE REPORT.   Int. J. Adv. Res. 10(09), 113-119.  DOI:10.21474/IJAR01/15330

• Chhalliyil P, Nandini U, Thota N. Uni5 Approach to Treat PCOS associated with Non-alcoholic Fatty Liver Disease: A Case Report. J Phytopharmacol 2022; 11(4):268-271. doi: 10.31254/phyto.2022.11407
• Pradheep Chhalliyil, Usha Nandini, Neelima thota. Uni5 approach to treating atopic eczema: a case report panacea journal of pharmacy and pharmaceutical sciences 2021:10(3), 01-09 http://internationaljournal.org.in/journal/index.php/pjpps/article/view/469/451 
• Pranav Chhaliyil, Bernd Schoel, Pradheep Chhalliyil. Assessing nonabrasive use of charcoal and its adsorptive microbial properties as a dentifrice. SRM journal of research in dental sciences |volume 12 | issue 2 | April-June 2021
• Chhalliyil, Pradheep.; Ilves, H.; Kazakov, S.A.; Howard, S.J.; Johnston, B.H.; Fagan, J. A Real-Time Quantitative PCR Method Specific for Detection and Quantification of the First Commercialized Genome-Edited Plant. Foods 2020, 9, 1245.
  
• Chhaliyil P, Fischer KF, Schoel B, Chhalliyil Pradheep. Impact of Different Bedtime Oral Cleaning Methods on Dental Damaging Microbiota Levels. Dent Hypotheses 2020; 11:40-6. DOI: 10.4103/denthyp.denthyp_7_20
• Chhaliyil P, Fischer KF, Schoel B, Chhalliyil Pradheep. A novel, simple, frequent oral cleaning method reduces damaging bacteria in the dental microbiota. Journal of International Society of Preventive and Community Dentistry. 2020 | DOI: 10.4103/jispcd.jispcd_31_20Part of ISSN: 2231-0762
• Pradheep Chhalliyil, John Fagan, Bernd Schoel. The superior performance of the Fast ID DNA extraction kit in isolation of high-quality DNA for qPCR analysis in complex food samples.1st Global Conference on GMO Analysis, Villa Erba, Como, Italy, 24-27 June 2008.
• Quirasco M, Schoel B, Chhalliyil P, Fagan J, Gálvez A. Real Time and Conventional PCR Detection of Liberty Link® Rice Varieties and Transgenic Soy in Rice Sampled in the Mexican and American Retail Market. Anal Bioanal Chem. 2008 Oct; 392(3):395-404
• Pradheep Kumar P Chhalliyil, Panneer Selvam N, Shanmugam G. Cleistanthin A causes DNA strand breaks and induces apoptosis in cultured cells. Mutat.Res-Gen.Tox. En. Jan 2000.464 :( 2)185-193.
• Stanulla M1, Chhalliyil P, Wang J, Jani-Sait SN, Aplan PD.Hum Mol Genet. 2001 Oct 15; 10(22):2481-91. Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context.

• S P Thandla 1, J E Ploski, S Z Raza-Egilmez, P P Chhalliyil, A W Block, P J de Jong, P D Aplan ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene. Blood 1999 Jan 1;93(1):293-9.

• Pradheep Kumar P Chhalliyil, and Govindaswamy Shanmugam. Anticancer potential of Cleistanthin A isolated from the tropical plant Cleistanthus collinus.Oncology Research.1999; 11, 5:225-232.
•  
• Kumar CPP, Pande G, Shanmugam G. Cleistanthin B causes G1 arrest and induces apoptosis in mammalian cells. Apoptosis 1998; 3:413-419.
• Prabahkaran C Kumar P, Panneerselvam N, Rajesh S, Shanmugam G. Cytotoxic and hemotoxic effects of cleistanthin B in normal and tumor cells. Mutagenesis. 1996:11: 553-557.
• Shanmugam G, Kumar CPP, Selvam NP, Apoptosis and chromosomal damage induced by cleistanthin B. Molecular Biology of the cell 1996; 7: 1119
• Work quoted in Book # ALTERNATIVES TO THE USE OF LIVE VERTEBRATES IN BIOMEDICAL RESEARCH AND TESTING 

TEACHING EXPERIENCE                                                                                                                        1990 to 1997

Lecturer in Biochemistry, P.S.G.College of Arts & Sciences, CBE.                        December 1990 – May 1992

Biochemistry theory & practicals for MSc Biology and Biotechnology at M. K. University (1992 -97).

SYLLABUS FRAMMING

Dr.Abithe Devi gave freedom to frame course syllabus and establishing the curriculum for graduate and undergraduate students studying biochemistry and biotechnology.Biochemistry, through which I brought all latest topics of Molecular Biology, Biotechnology, Nutritional Science etc. She said after 1990 many universities of India had updated their syllabus based on this.  

FELLOWSHIPS AWARDED

UGC Lectureship 1990 (University Grants Commission)

ICAR Biotechnology 1991 (Indian council of Agri. Research)

UGC-CSIR JRF 1992 (Council of Scientific & Industrial Research).

UGC-CSIR SRF 1994 (Council of Scientific & Industrial Research).

AWARDS

 The first “Anna Memorial GOLD AWARD”, for the best Ph.D. thesis published in the cancer field (India).

Winner-Book Award 2004at Hollywood Spiritual Film Festival

BOOK WRITTEN & PUBLISHED

Incompatible Foods (Virudh Aaahar) English September 2022

Deivamum Deiveega Sakthigalum: Tamil   (August 11, 2020)

Journey to the Source, Decoding Matrix Trilogy, Sakthi Books 2004, Iowa.

“Putrunoyyium Unavum” (Diet & Cancer- Co-author Dr.M.Madeswaran) Tamil, 1997, Maruthi Publishers, Coimbatore, India.

"Bhakshanavum Cancerum" Malayalam, Sakthi Foundation 2013, USA - Co-Author-Dr.M.Thomas).

25 million view hits with more than  2000 pages of information on the web on Health, Relationships, Parenting, Education, Spirituality, Selftuality, and Community Responsibility.

CONFERENCES

• First International Comprehensive Cancer Care conference: Center for mind-body medicine. 12-14th June 1998, Washington DC, USA (Full scholarship was given to attend the conference).
• First International Congress on Tibetian Medicine: 7-9th November 1998, Washington DC, USA (Full scholarship was given to attend the conference).
• 1st Global Conference on GMO Analysis, Villa Erba, Como, Italy, 24-27 June 2008, GM rice screening in the Mexican market by real-time PCR.
• Pittcon Conference 2007, 2009, 2012, 2016 8. PAG Plant Animal Genome conference – 2008, 2012-2019 9. Real-Time Conference - 2007 • G-OnRamp Workshop Agenda 2018 Washington University in St. Louis, July 16-19

https://plan.core-apps.com/pag_2019/abstract/6e070c0ebde6a5b908f9f08fb2edf257 
PO0203 In vitro Effect of Sugarcane Polyphenols on Oral Microbiota
Pranav Chhalliyil, Pradheep Chhalliyil, and Bernd Schoel

https://pag.confex.com/pag/xxv/meetingapp.cgi/Person/48037 
P1204 A Rapid Method for Extraction and Purification of DNA from Dental Plaque, Tongue Scraping and Saliva Using IDeal Kit 2017 INTLPAG.ORG
Pranav Chhalliyil, Pradheep Chhalliyil, and Bernd Schoel, Genetic ID NA, Inc, Fairfield, IA

https://pag.confex.com/pag/xxiv/webprogram/Session3477.html 
P0206 IDeal Fast ID Kit for DNA Extractions from Saliva Samples. Jan 9-13 2016 INTLPAG.ORG Pranav Chhaliyil, Genetic-ID; Bernd Schoel, Pradheep Chhalliyil
P0216 High PCR Efficiency Using Ideal DNA Extraction Kit an 9-13 2016 INTLPAG.ORG Pradheep Chhalliyil, Bernd Schoel, Genetic ID NA, Inc

https://pag.confex.com/pag/xxiii/webprogram/Paper16389.html 
P0061 Quantitative Digital and Real Time PCR for GM Alfalfa January 12, 2015 Pradheep Chhalliyil, Bernd Schoel , Genetic ID NA, Inc, Fairfield, IA

https://pag.confex.com/pag/xxiii/webprogram/Paper15169.html 
P0045 High PCR Efficiency Using FASTMAG DNA Extraction Kit January 12, 2015 Pradheep Chhalliyil, Bernd Schoel , Genetic ID NA, Inc, Fairfield, IA

ADDITIONAL

LinkedIn Professional Comments: (REVIEWS)

John Fagan Ph.D.John Fagan Ph.D.· 1stFirst degree connection

Chairman and Chief Scientist at Health Research Institute - HRI LabsChairman and Chief Scientist at Health Research Institute - HRI Labs September 14, 2020, John managed Pradheep directly September 14, 2020, John managed Pradheep directly

While I was Chairman and Chief Scientific Officer at Genetic ID/Global ID Group (now FoodChain ID), Pradheep played a key role in technology development over many years. He was consistently creative and innovative, thinking outside the box to deliver solutions that were often much better than what was expected. His innovations in PCR and DNA extraction saved the company millions of dollars throughout his tenure at the company. I considered him a key corporate asset that added substantial value to the company. He is also highly idealistic and has continuously worked as a leader in poverty removal projects in his native India, giving his time and resources to improving the quality of life for rural people. He is also easy to work with, cooperative and helpful to colleagues, and has excellent communication skills. Highly recommended on all counts!

Brian H. JohnstonBrian H. Johnston· 1stFirst degree connection

Founder and CEO, SomaGenics, Inc. Founder and CEO, SomaGenics, Inc. November 6, 2019, Brian H. managed Pradheep directly November 6, 2019, Brian H. managed Pradheep directly

I recently met Pradheep through a friend and collaborator, and on his recommendation, I engaged Pradheep to help solve a very challenging genomics problem. His ideas for solutions were spot-on and within a few weeks, he had solved the problem, generated all the proof of concept data, and documented his work clearly and comprehensively. He is very knowledgeable, resourceful, and efficient in designing and executing experiments. He is also a delight to work with, considerate, cheerful, and always ready to chat about science.

Bill Thompson· 1stFirst degree connection

Chief Executive Officer Chief Executive Officer August 2, 2011, Bill was senior to Pradheep but didn't manage Pradheep directly August 2, 2011, Bill was senior to Pradheep but didn't manage Pradheep directly

Pradheep is an exceptional scientist. He embodies a rare combination of deep intellectual and analytical abilities combined with a highly creative and intuitive approach to problem-solving very complex scientific challenges. His highly desirable skill set makes him an ideal person to have on board one's Research and Development Team.
Over the 7 years, I worked with Pradheep. I have witnessed him succeed in achieving the goals set for him time after time. This included developing breakthroughs in GMO testing methods and establishing new technologies for the company. Additionally, Pradheep as a person is wonderful to work with. His personality and his positive attitude to work and life make him a complete pleasure to interact with daily.

 MY Stories

Cleistanthin

From a Toxic Plant to a Cancer Discovery — A 30-Year Journey

The idea of using a toxic plant for cancer treatment came to me during college, when I was deeply fascinated by how mitochondria generate energy for cells — including cancer cells. I began to wonder: Could I selectively inhibit mitochondrial energy production in cancer cells? These thoughts often turned into lively discussions with Dr. Abitha Devi, who shared my passion for the chemiosmotic theory of ATP generation.

Back then, I knew some plants used in suicides — those containing cyanide, for example — could block mitochondrial energy production. But I was searching for something different: a plant that wouldn’t kill instantly, but would act slowly and selectively, potentially useful for targeting cancer cells. 

In 1992, I was fortunate to join the lab of Dr. G. Shanmugam at MKU. I was assigned to work on P53-like anti-oncogene and its mutations in cell culture, but my childhood fascination with Indian home remedies, folk medicine, Ayurveda, and Siddha continued to influence my perspective. My project though involved cell culture and oncogenes, and I started exploring toxic plants from my hometown in Kerala.

Around this time, I met Sendurai Mani, who was doing his MSc project. We quickly became friends. During a weekend trip to Palani Temple, I shared my fascination with the Navapashanam idol — nine toxic substances said to form the divine image of Lord Muruga.

This sparked a deeper conversation. I asked Mani if he knew of any toxic plants from his village. Though he wasn’t sure, he promised to ask his grandmother, who was knowledgeable about traditional herbs. Soon, his father sent us a plant known locally as “Oduvan Thalai,” commonly associated with suicides. Cleistanthus collinus is the botanical name.

On February 3, 1993, at 4 a.m., driven by curiosity, we prepared a crude methanolic extract of the plant and tested it on cancer cell cultures. I didn’t tell my guide right away — I confided only in my seniors, who dismissed my idea as a waste of time and lab resources. They warned me I might be thrown out for misusing materials.

But under the microscope, I saw something unusual — a clear change in cell behavior.

At lunch, I finally gathered the courage to tell Dr. Shanmugam. He said nothing and simply walked away. The entire day, I was filled with fear. That evening at 8:30 p.m., I got a call on the hostel phone. My hands trembled as I picked it up.

To my surprise, it was Dr. Shanmugam. “What did you add to the culture?” he asked. He had been thinking about it all day. He wanted to know everything — the plant, the extraction method, the dosage. I answered, breathless with relief. He then said, “Repeat it and show me tomorrow.”

That moment changed my life. Within six months, this work became my PhD topic.

The Cleistanthin Breakthrough

Through intense exploration, we identified Cleistanthin — the active anticancer compound in Cleistanthus collinus. From 1993 to 1997, I immersed myself in refining and validating the compound’s activity, combining traditional herbal knowledge with rigorous molecular and biochemical techniques.

My PhD work on Cleistanthin involved:

✅ Screening more than 38 cancer cell lines at NTCC, Pune
✅ Performing flow cytometry (FACS) at CCMB
✅ Running Comet assays, oxidative damage, TBARS, antioxidative studies
✅ Conducting chromosomal karyotyping and mouse-induced cancer studies
✅ Purifying Cleistanthin through over 6,000 TLC plates, large solvent separation columns, and spectroscopic analyses
✅ Blood biochemistry in mice receiving Cleistanthin, My sincere gratitude to all the mice used in animal models — unwilling heroes who validated the tumor effects

Oncogene plasmids from Dr. Bert Vogelstein (Johns Hopkins) for molecular studies

Notably, Cleistanthin showed superior efficacy compared to known chemotherapy drugs like Tamoxifen and Etoposide, with low side effects on blood cells — a fact that even impressed researchers at a Boston lab.

in 1998 Dr.G.S gave my purified compound to his senior students who did not take it serious and so passed on to someone else. A Boston lab did and thrilled with his sensitivity and specificity on cancer cells and wanted to license it from Dr.G.S and myself. Unfortuntaly the patent expiry for global made investors backup from developing it further. 

I will always be grateful to Dr. G. Shanmugam. His open mind, encouragement, and unwavering support turned an unconventional idea into a full-fledged research project. Later, I was able to support his health with my own herbal knowledge — a small gesture of thanks for what I could never truly repay.

Our work eventually attracted attention. Tamil newspapers like Hindu Tamil, Bhagya, and Manorama, and even some North Indian TV channels — perhaps even ABC or BBC — reported on it. Letters poured in from people seeking cancer treatment. I had to reply humbly: “This is still in the research phase.”

Behind the scenes, many people helped:

• Nataraj, Pandi, Subash — my fellow researchers

• Dr. Panneer Selvam — who studied chromosomal aberrations

• Rajesh, my MSc project student, who spent long hours working

• Meenakshi, who made it her PhD project

• Mr. Prem Kumar (Chemistry Dept) and many others. With prem I applied one more patent for singlet oxygen water purification. I also got the idea of using ionic changes with nucleotide changes which I thought to use for DNA sequencing. No one encouraged me plus I was too busy with this work. Later when I saw Nanopore technology, i recollected that I had thought that a decade back about it. 

We filed a patent, but unfortunately it was only a process patent — not internationally protected, and it eventually expired.

When no one came forward to take this work further, Sendurai Mani suggested we start a company together. I proposed the name Sathgen. Mani worked tirelessly, secured investors, and refined the original compound. Today, after 30 years, it has reached clinical trials and is showing positive results.

I am overwhelmed with gratitude — to Dr. G. Shanmugam, to Sendurai Mani and Somaiyya, and to everyone who supported or challenged me. Out-of-the-box thinking is often ridiculed, as I experienced since childhood. But with the right mentor and faith in the work, even the most unconventional ideas can shape reality.

What began as a spark in 1993 is now a ray of hope for cancer patients. Sathgen has modified the Clesitanthin compound and related derivatives that I purified, following the tradition of eminent chemists like Prof. Govindachari. They have synthesized and patented many derivatives, and now — thanks to the perseverance of Sendurai Mani and  Samir Somaiya Sathgen Therapeutics— these compounds have entered human clinical trials.

🙏 Thank you to everyone who made this journey possible.

This work is still motivating other researchers to work on these compounds.  https://www.alliedacademies.org/conference-abstracts-files/molecules-targeting-cancer-stem-cells.pdf  Godvari Refinieries ,  Sathgen,  a company has studied the effect on clesitanthin and its derivatives. 

A pub med search https://www.ncbi.nlm.nih.gov/pmc/?term=cleistanthin++cancer

Ph.D Work: Cleistanthin as Anti-cancer agent

News in "The Hindu"

News in Tamil Paper

News in Malayalam Paper 

https://orcid.org/0000-0001-9167-0621

Work quoted in Book

1--#

ALTERNATIVES TO THE USE OF LIVE VERTEBRATES IN BIOMEDICAL RESEARCH AND TESTING : A bibliography with Abstracts: Prepared by NATIONAL LIBRARY OF MEDICINE NATIONAL INSTITUTES OF HEALTH BETHESDA, MD USA.by Vera W. Hudson, M.S. Project Coordinator and Scientific Editor, National Library of Medicine and Elizabeth DeBerry, Copy Editor, National Library of Medicine: 1997 No. 3.

Cytotoxic and genotoxic effects of cleistanthin B in normal and tumor cells. Prabhakaran C Kumar P, Panneerselvam N, Rajesh S, Shanmugam G.

2. Quick Tips for Balanced Living:Himalayan Institute Press-2005. Inner Cleansing by Pradheep Chhalliyil -Page 32-34.

3. From Superman to Brahman: The Religious Shift of The Matrix Mythology

http://digitalcommons.unomaha.edu/cgi/viewcontent.cgi?article=1622&context=jrf    

Journal of Religion and Film, Jeffery Wittung, Daniel Bramer Volume 10 Issue 2 October 2006

4. ONE: ESSENTIAL WRITINGS ON NONDUALITY -Jerry Katz

Uni5 Sakthi Foundation & Uni5 Sakthi Schools 

 Co-Founded Uni5 Sakthi Foundation INC

• A Tax exempted Non-Profit (Community Profiting) organization operating in USA, India, and Indonesia and doing various charitable activities.
• Giving health information to hundreds of people all over the globe for various ailments.
• Help to fund underprivileged children, orphans for their school education.
• Bring awareness among underprivileged people through health camps, such as “eye camps”, and diabetic camps in remote areas of Tamil Nadu.
• Create Audiovisual materials to help create health awareness.
• Started the first free or pay-as-capable Uni5schools in Sendurai (Madurai), Coimbatore, Porayar (as opposed to middle/upper-class oriented schools in urban locations). (www.sakthischools.org)
• Support the work of other non-profit (NGO's) organizations.

AMMAGENOMICS

In 2021, after visiting our parents in Chennai, we decided to return to Arizona, where we had previously registered AMMAGENOMICS. However, the COVID-19 pandemic made it challenging to return to the USA. During this time, my classmate Mr.Ganesan asked me why I wasn't contributing to the creation of COVID testing kits. For research purpose my wife Priya was instrumental is setting a lab in Chennai, and due to excellent customer service we had to employ more than 30 people and helped the community in giving 3 hours results. After this these customers turned towards us for quick blood and other diagnostic services.  

OORJV 

I first considered the concept of Oorj while I was in the USA over a decade ago. My journey toward healthier food choices began back in 1997 when I started consuming organic milk, as that was the primary option available at the time in Buffalo, USA. However, it wasn't until around 2000 that I had access to a more extensive range of organic foods. At that time, the terms "organic" and "non-GMO" were commonly used, but it's important to note that not all organic foods were necessarily non-GMO. If a food item had undergone genetic modification, it was considered GMO, while non-GMO or traditional heirloom referred to those that hadn't.
It's also crucial to distinguish between GMO and hybrid foods. The misconception that organic food is entirely pesticide-free is incorrect; there are specific regulations that govern which pesticides can be used in organic farming.
During the process of obtaining organic certification, questions are answered, and recommendations are made. Soil samples are rarely tested. These tests aren't typically used to certify products.
I developed several novel technologies in a USA company, not just for widely produced crops like soybeans and maize but also for processed foods. This eventually led to the non-GMO initiative. This initiative involved certifying non-GMO food through genetic analysis.
Around 2010, the market started overflowing with organic products as the awareness of organic food's health benefits grew. People began to switch to organic options. I remember a conversation with my wife in a store, where we realized that earlier, organic choices were limited to specific products like olive oil or sesame oil. However, with time, organic options became more diverse, and the question arose, "With so many options available now, how do consumers decide?"

Shop Awareness - Kapila Nalam
This led to the idea of shop awareness. I initiated the process to register in India with my friends including Thanigai, Muthu, Ripunjaya, Viola, Jayaram, Vijay, Pongalur Gomathi Ganesan (Who later took it forward as www.kapilanalam.com) .

I was particularly interested in the polyphenol content of foods, as I believed in their significant health benefits. Polyphenols are known for their anti-inflammatory and antioxidant properties, and they can delay the onset of various aging-related disorders and diseases. I started testing polyphenols, and my interest in their health benefits expanded.
In 2021, after visiting our parents in Chennai, we decided to return to Arizona, where we had previously registered AMMAGENOMICS. However, the COVID-19 pandemic made it challenging to return to the USA. After this time, continued testing foods rich in polyphenols, which eventually led to the formation of AMMAGENOMICS and OORJV. Our journey started with testing for polyphenols, and over time, we began to test a wider range of foods.
As we received more food samples from customers, we observed that adulteration was becoming more prevalent in India than in other places. This led to my decision to move to India, as I consider it vital to consume foods rich in polyphenols. We noticed that young members of our lab staff in India were consuming a lot of junk food. To encourage them to adopt healthier eating habits, I introduced OORJ-certified foods. We even conducted tests to measure polyphenol levels in their blood, which confirmed the health benefits of consuming polyphenol-rich foods.
OORJ certification ensures that the food you consume is of high quality. Unlike organic products, OORJV-certified items undergo rigorous testing, including checks for pesticide residues and adulteration. The certification aims to provide consumers with a trusted way to ensure the quality of the foods they eat.
We have identified farmers throughout India who use traditional pesticide-free methods and tested not only for polyphenol levels but also other aspects of food quality. Our goal is to provide consumers with confidence in the safety and health benefits of the food they consume.
This initiative is essential not only for organic foods but also for foods with medicinal properties, as we recognize the importance of healthy eating. We aim to make OORJ a valuable player in the global market.
AMMAGENOMICS differs slightly from OORJV and has been validated and tested by OORJV. While all the testing and examinations are performed by AMMAGENOMICS, OORJ ensures that the testing and other requirements are met, which is akin to a certification process. The difference lies in the fact that the University awards the certification.
This is how we distinguish ourselves from other testing companies, and we have plans to expand our services to the USA and other countries. The market is currently inundated with various claims about food quality, and our goal is to provide consumers with reliable information and certification. As a result, more sellers are starting to market OORJ-certified products, and our impact on the food industry is growing.
Our commitment extends beyond polyphenols to other aspects of food quality and safety. We want consumers to be certain about the foods they consume, and our rigorous testing and certification process aims to achieve this.

Links to Talks

Topics of Talks

1. Health and luck factor !. More modern scientific research shows that more than genetics, environment and life style, diseases like cancer is caused by randomness. The talk will be about luck in life, how to understand it and how to increase it. The content is totally different from the common views of information not thought about by doctors or health professionals.

2. Successful Parenting !. This topic is about the five needs of a child that is taken care from the young age will guarantee success in a child's life. This will help to avoid stress both in the parents and the child. This is based on practically tried and found effective.

3. Happy and successful Carreer !.This talk helps adults and students to find the job enjoyable and successful. It also addresses what career one should choose and find happiness in all five levels of being.

4. Simplified Bhagavad Gita !.One of the most practical solutions for all day to day life problems we encounter. This one hour talk will give you the essence of Gita that you it will make sense the geniousness of the Ancient Indian thought on encountering life situations.

5. Can one Education pattern be effective for effective personal and professional life !. This talk brings evidence how a pattern based education can help all students, adults about a pattern based learning system that will make one brilliant in arts, science, maths and at the same time understand the mystery of oneself and the Universe.

 https://www.youtube.com/watch?v=fW-XZnTc-9w&app=desktop

Details

Parent Category: uni5 Community

Category: About Uni5

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Uni5 Logo

  For everyone their own Self is important than anything in this world. In fact all that exist for every one is their inner Self and the external Universe. The outer and inner is made up of only Energy. Though this Energy inside and outside is only one and Same, we have a duality of "I" and other matter. Then we have a question where did I and this matter come and is there a connection or not.

To make this concept understand in a easy way, we view this single Universal Energy  manifestation in a pattern of five phenomenal states. The Universal Self pattern refers to the five pattern of Energy.

 This five pattern is also seen within us as our

1. Physical (occupying space-time) Body,

2.Chemical (interactive) Mind,

3. Mathematical (calculating) Intelligence, 

4. Biological (living) Awareness and

5. Selftual (all embracing) Consciousness.

 The individual has the choice to recongize one's own Self to be the changing physical body and emotional mind or the cognizing intelligence or the Self awareness or the Community Self Consciousness.

Being in the Self Awareness/ Consciouness state is Selftual, the core message of Uni5 Community.

Every choice comes with a result. Identifying oneself to the changing body and mind results in fear of old-age, death and decay.

Identifying oneself to the intelligence results in confidence in realizing the reality of Energy evolution of the Universe.

Identifying oneself to the Self-Awareness results in being the inner Evolution.

Identifying oneself to the Community Self Consciousness results in a Eternal steady state of existence.

 Everlasting happiness comes when the individual Self is connected to the Community Self. This is shown by the invidual self pointing finger (fore-finger) joining the thumb finger denoting the Community Self Consciousness.

The single Universal Energy expanded in five process to this existing Universe. Then this Energy goes back to the same Source. The five hands and the U gives the meaning that all that came goes back to the source (inclined C shape).

In the logo the five fingers are five in number, uni5 is four in number, All that is 3 in number, I am is two in number , Eternal is one in number.

The word "I am Eternal" refers to the state when the individual transcends to the state of a community Self. At this state  the indivudal self recognizes the Single Universal Energy state.

Energy can neither be created nor destroyed (Eternal) only transformed from one form to another. So our Self is Eternal.

Five Uni5 Principles

 1. Thumb - The Purpose of life is to be happy.

 2. Index -  "As is the Macro-Universe (our outer) so is the Micro-Universe (our inner)".

 3. Middle - The Universal Energy can neither be created nor destroyed but transform from one form to another.

4. Ring - Transformation (evolution) of the mind to higher level of views  is inevitable for happy life.

5. Little -Every action has an effect and so choose actions that bring Eternal happiness.

The Hierarchy Uni5 Triangle and Selftual Circle: When we identify ourself with our physical body, emotional mind and intellectual logics, there is a hierarchy of superiority. In the Self level, there is only the Self at its center and any size circle with a range of circumference could be drawn. Our Self (image) is determined by how far we embrace this universe. 

Sarvam khalvidam Evaham Nanya Dashti Sanathanam- All that is, I am, Eternal.